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Hiding in Plain Sight: an Approach to Treating Patients with Severe COVID-19 Infection.
Fedson, David S; Opal, Steven M; Rordam, Ole Martin.
mBio ; 11(2)2020 03 20.
Article in English | MEDLINE | ID: covidwho-11461

ABSTRACT

Patients with COVID-19 infection are at risk of acute respiratory disease syndrome (ARDS) and death. The tissue receptor for COVID-19 is ACE2, and higher levels of ACE2 can protect against ARDS. Angiotensin receptor blockers and statins upregulate ACE2. Clinical trials are needed to determine whether this drug combination might be used to treat patients with severe COVID-19 infection.


Subject(s)
Betacoronavirus , Coronavirus Infections/metabolism , Coronavirus Infections/therapy , Pneumonia, Viral/metabolism , Pneumonia, Viral/therapy , Receptor, Angiotensin, Type 2/biosynthesis , Receptors, Virus/biosynthesis , Angiotensin II Type 2 Receptor Blockers/therapeutic use , Angiotensin-Converting Enzyme 2 , COVID-19 , Coronavirus Infections/drug therapy , Coronavirus Infections/virology , Humans , Hydroxymethylglutaryl-CoA Reductase Inhibitors/therapeutic use , Peptidyl-Dipeptidase A/metabolism , Pneumonia, Viral/virology , Receptors, Coronavirus , SARS-CoV-2 , COVID-19 Drug Treatment
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